LW6 enhances chemosensitivity to gemcitabine and inhibits autophagic flux in pancreatic cancer

The efficacy of gemcitabine therapy is often insufficient for the treatment of pancreatic cancer. The current study demonstrated that LW6, a chemical inhibitor of hypoxia-inducible factor 1α, is a promising drug for enhancing the chemosensitivity to gemcitabine. LW6 monotherapy and the combination t...

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Bibliographic Details
Main Authors: Xianbin Zhang, Simone Kumstel, Ke Jiang, Songshu Meng, Peng Gong, Brigitte Vollmar, Dietmar Zechner
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Journal of Advanced Research
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123219300840