Induction of CD4+CD25+FOXP3+ regulatory T cells by mesenchymal stem cells is associated with modulation of ubiquitination factors and TSDR demethylation

Induction of CD4+CD25+FOXP3+ regulatory T cells by mesenchymal stem cells is associated with modulation of ubiquitination factors and TSDR demethylation

Abstract Background Mesenchymal stem cells (MSCs) are known for their ability to induce the conversion of conventional T cells (Tconvs) into induced regulatory T cells (iTregs) in specific inflammatory contexts. Stable Foxp3 expression plays a major role in the phenotypic and functional stability of...

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Bibliographic Details
Main Authors: Maryam Khosravi, Ali Bidmeshkipour, José L. Cohen, Ali Moravej, Suzzan Hojjat-Assari, Sina Naserian, Mohammad Hossein Karimi
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Regulatory T cells
Ubiquitination molecules
Online Access:http://link.springer.com/article/10.1186/s13287-018-0991-1

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http://link.springer.com/article/10.1186/s13287-018-0991-1

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