Memory-Like Inflammatory Responses of Microglia to Rising Doses of LPS: Key Role of PI3Kγ

Memory-Like Inflammatory Responses of Microglia to Rising Doses of LPS: Key Role of PI3Kγ

Trained immunity and immune tolerance have been identified as long-term response patterns of the innate immune system. The causes of these opposing reactions remain elusive. Here, we report about differential inflammatory responses of microglial cells derived from neonatal mouse brain to increasing...

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Bibliographic Details
Main Authors: Trim Lajqi, Guang-Ping Lang, Fabienne Haas, David L. Williams, Hannes Hudalla, Michael Bauer, Marco Groth, Reinhard Wetzker, Reinhard Bauer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
microglia
PI3Kγ
LPS
β-glucan
training
tolerance
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02492/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02492/full

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