Truncation or Deglycosylation of the Neuraminidase Stalk Enhances the Pathogenicity of the H5N1 Subtype Avian Influenza Virus in Mallard Ducks

Truncation or Deglycosylation of the Neuraminidase Stalk Enhances the Pathogenicity of the H5N1 Subtype Avian Influenza Virus in Mallard Ducks

H5N1 subtype avian influenza virus (AIV) with a deletion of 20 amino acids at residues 49–68 in the stalk region of neuraminidase (NA) became a major epidemic virus. To determine the effect of truncation or deglycosylation of the NA stalk on virulence, we used site-directed mutagenesis to insert 20...

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Bibliographic Details
Main Authors: Sujuan Chen, Keji Quan, Dandan Wang, Yinping Du, Tao Qin, Daxin Peng, Xiufan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Microbiology
Subjects:
H5N1 subtype AIV
neuraminidase
glycosylation
pathogenicity
mallard duck
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.583588/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2020.583588/full

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