Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors
In recent years, the functions of glial cells, namely, astrocytes and microglia, have gained prominence in several diseases of the central nervous system, especially in glioblastoma (GB), the most malignant primary brain tumor that leads to poor clinical outcomes. Studies showed that microglial cell...
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Frontiers Media S.A.
2018-08-01
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Series: | Frontiers in Cellular Neuroscience |
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Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2018.00235/full |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Diana Matias Diana Matias Joana Balça-Silva Joana Balça-Silva Joana Balça-Silva Grazielle C. da Graça Caroline M. Wanjiru Caroline M. Wanjiru Lucy W. Macharia Lucy W. Macharia Carla Pires Nascimento Carla Pires Nascimento Natalia R. Roque Juliana M. Coelho-Aguiar Cláudia M. Pereira Marcos F. Dos Santos Luciana S. Pessoa Flavia R. S. Lima Alberto Schanaider Valéria P. Ferrer Tania Cristina Leite de Sampaio e Spohr Vivaldo Moura-Neto Vivaldo Moura-Neto Vivaldo Moura-Neto |
spellingShingle |
Diana Matias Diana Matias Joana Balça-Silva Joana Balça-Silva Joana Balça-Silva Grazielle C. da Graça Caroline M. Wanjiru Caroline M. Wanjiru Lucy W. Macharia Lucy W. Macharia Carla Pires Nascimento Carla Pires Nascimento Natalia R. Roque Juliana M. Coelho-Aguiar Cláudia M. Pereira Marcos F. Dos Santos Luciana S. Pessoa Flavia R. S. Lima Alberto Schanaider Valéria P. Ferrer Tania Cristina Leite de Sampaio e Spohr Vivaldo Moura-Neto Vivaldo Moura-Neto Vivaldo Moura-Neto Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors Frontiers in Cellular Neuroscience glioblastoma astrocytes microglia crosstalk cytokines molecular mechanisms |
author_facet |
Diana Matias Diana Matias Joana Balça-Silva Joana Balça-Silva Joana Balça-Silva Grazielle C. da Graça Caroline M. Wanjiru Caroline M. Wanjiru Lucy W. Macharia Lucy W. Macharia Carla Pires Nascimento Carla Pires Nascimento Natalia R. Roque Juliana M. Coelho-Aguiar Cláudia M. Pereira Marcos F. Dos Santos Luciana S. Pessoa Flavia R. S. Lima Alberto Schanaider Valéria P. Ferrer Tania Cristina Leite de Sampaio e Spohr Vivaldo Moura-Neto Vivaldo Moura-Neto Vivaldo Moura-Neto |
author_sort |
Diana Matias |
title |
Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors |
title_short |
Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors |
title_full |
Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors |
title_fullStr |
Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors |
title_full_unstemmed |
Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors |
title_sort |
microglia/astrocytes–glioblastoma crosstalk: crucial molecular mechanisms and microenvironmental factors |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular Neuroscience |
issn |
1662-5102 |
publishDate |
2018-08-01 |
description |
In recent years, the functions of glial cells, namely, astrocytes and microglia, have gained prominence in several diseases of the central nervous system, especially in glioblastoma (GB), the most malignant primary brain tumor that leads to poor clinical outcomes. Studies showed that microglial cells or astrocytes play a critical role in promoting GB growth. Based on the recent findings, the complex network of the interaction between microglial/astrocytes cells and GB may constitute a potential therapeutic target to overcome tumor malignancy. In the present review, we summarize the most important mechanisms and functions of the molecular factors involved in the microglia or astrocytes–GB interactions, which is particularly the alterations that occur in the cell’s extracellular matrix and the cytoskeleton. We overview the cytokines, chemokines, neurotrophic, morphogenic, metabolic factors, and non-coding RNAs actions crucial to these interactions. We have also discussed the most recent studies regarding the mechanisms of transportation and communication between microglial/astrocytes – GB cells, namely through the ABC transporters or by extracellular vesicles. Lastly, we highlight the therapeutic challenges and improvements regarding the crosstalk between these glial cells and GB. |
topic |
glioblastoma astrocytes microglia crosstalk cytokines molecular mechanisms |
url |
https://www.frontiersin.org/article/10.3389/fncel.2018.00235/full |
work_keys_str_mv |
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doaj-0a07001490dd4914b4540aefd8323b452020-11-24T21:07:58ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022018-08-011210.3389/fncel.2018.00235395202Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental FactorsDiana Matias0Diana Matias1Joana Balça-Silva2Joana Balça-Silva3Joana Balça-Silva4Grazielle C. da Graça5Caroline M. Wanjiru6Caroline M. Wanjiru7Lucy W. Macharia8Lucy W. Macharia9Carla Pires Nascimento10Carla Pires Nascimento11Natalia R. Roque12Juliana M. Coelho-Aguiar13Cláudia M. Pereira14Marcos F. Dos Santos15Luciana S. Pessoa16Flavia R. S. Lima17Alberto Schanaider18Valéria P. Ferrer19Tania Cristina Leite de Sampaio e Spohr20Vivaldo Moura-Neto21Vivaldo Moura-Neto22Vivaldo Moura-Neto23Instituto Estadual do Cérebro Paulo Niemeyer – Secretaria de Estado de Saúde, Rio de Janeiro, BrazilInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto Estadual do Cérebro Paulo Niemeyer – Secretaria de Estado de Saúde, Rio de Janeiro, BrazilCenter for Neuroscience and Cell Biology and Institute for Biomedical Imaging and Life Sciences Consortium, University of Coimbra, Coimbra, PortugalFaculty of Medicine, University of Coimbra, Coimbra, PortugalInstituto Estadual do Cérebro Paulo Niemeyer – Secretaria de Estado de Saúde, Rio de Janeiro, BrazilInstituto Estadual do Cérebro Paulo Niemeyer – Secretaria de Estado de Saúde, Rio de Janeiro, BrazilInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto Estadual do Cérebro Paulo Niemeyer – Secretaria de Estado de Saúde, Rio de Janeiro, BrazilPrograma de Pós-Graduação em Anatomia Patológica, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto Estadual do Cérebro Paulo Niemeyer – Secretaria de Estado de Saúde, Rio de Janeiro, BrazilPrograma de Pós-Graduação em Anatomia Patológica, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto Estadual do Cérebro Paulo Niemeyer – Secretaria de Estado de Saúde, Rio de Janeiro, BrazilInstituto Estadual do Cérebro Paulo Niemeyer – Secretaria de Estado de Saúde, Rio de Janeiro, BrazilUniversidade do Grande Rio (Unigranrio), Duque de Caxias, BrazilInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto Estadual do Cérebro Paulo Niemeyer – Secretaria de Estado de Saúde, Rio de Janeiro, BrazilInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilCentro de Cirurgia Experimental do Departamento de Cirurgia da Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto Estadual do Cérebro Paulo Niemeyer – Secretaria de Estado de Saúde, Rio de Janeiro, BrazilInstituto Estadual do Cérebro Paulo Niemeyer – Secretaria de Estado de Saúde, Rio de Janeiro, BrazilInstituto Estadual do Cérebro Paulo Niemeyer – Secretaria de Estado de Saúde, Rio de Janeiro, BrazilInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilUniversidade do Grande Rio (Unigranrio), Duque de Caxias, BrazilIn recent years, the functions of glial cells, namely, astrocytes and microglia, have gained prominence in several diseases of the central nervous system, especially in glioblastoma (GB), the most malignant primary brain tumor that leads to poor clinical outcomes. Studies showed that microglial cells or astrocytes play a critical role in promoting GB growth. Based on the recent findings, the complex network of the interaction between microglial/astrocytes cells and GB may constitute a potential therapeutic target to overcome tumor malignancy. In the present review, we summarize the most important mechanisms and functions of the molecular factors involved in the microglia or astrocytes–GB interactions, which is particularly the alterations that occur in the cell’s extracellular matrix and the cytoskeleton. We overview the cytokines, chemokines, neurotrophic, morphogenic, metabolic factors, and non-coding RNAs actions crucial to these interactions. We have also discussed the most recent studies regarding the mechanisms of transportation and communication between microglial/astrocytes – GB cells, namely through the ABC transporters or by extracellular vesicles. Lastly, we highlight the therapeutic challenges and improvements regarding the crosstalk between these glial cells and GB.https://www.frontiersin.org/article/10.3389/fncel.2018.00235/fullglioblastomaastrocytesmicrogliacrosstalkcytokinesmolecular mechanisms |