Elastic transformation of histological slices allows precise co-registration with microCT data sets for a refined virtual histology approach

Abstract Although X-ray based 3D virtual histology is an emerging tool for the analysis of biological tissue, it falls short in terms of specificity when compared to conventional histology. Thus, the aim was to establish a novel approach that combines 3D information provided by microCT with high spe...

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Bibliographic Details
Main Authors: Jonas Albers, Angelika Svetlove, Justus Alves, Alexander Kraupner, Francesca di Lillo, M. Andrea Markus, Giuliana Tromba, Frauke Alves, Christian Dullin
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-89841-w