Progesterone Neuroprotection in the Wobbler Mouse, a Genetic Model of Spinal Cord Motor Neuron Disease

Progesterone Neuroprotection in the Wobbler Mouse, a Genetic Model of Spinal Cord Motor Neuron Disease

Motor neuron degeneration characterizes the spinal cord of patients with amyotrophic lateral sclerosis and the Wobbler mouse mutant. Considering that progesterone (PROG) provides neuroprotection in experimental ischemia and injury, its potential role in neurodegeneration was studied in the murine mo...

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Bibliographic Details
Main Authors: Marı́a Claudia Gonzalez Deniselle, Juan José López-Costa, Jorge Pecci Saavedra, Luciana Pietranera, Susana L. Gonzalez, Laura Garay, Rachida Guennoun, Michael Schumacher, Alejandro F. De Nicola
Format: Article
Language:English
Published: Elsevier 2002-12-01
Series:Neurobiology of Disease
Subjects:
neuroprotection
progesterone
spinal cord
neurodegeneration
Wobbler mice
amyotrophic lateral sclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102905644

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http://www.sciencedirect.com/science/article/pii/S0969996102905644

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