Partial mGlu5 Negative Allosteric Modulator M-5MPEP Demonstrates Antidepressant-Like Effects on Sleep Without Affecting Cognition or Quantitative EEG

Partial mGlu5 Negative Allosteric Modulator M-5MPEP Demonstrates Antidepressant-Like Effects on Sleep Without Affecting Cognition or Quantitative EEG

Selective negative allosteric modulators (NAMs) targeting the metabotropic glutamate receptor subtype 5 (mGlu5) demonstrate anxiolytic-like and antidepressant-like effects yet concern regarding adverse effect liability remains. Functional coupling of mGlu5 with ionotropic N-methyl-D-aspartate recept...

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Bibliographic Details
Main Authors: Kimberly M. Holter, Alex D. Lekander, Christina M. LaValley, Elizabeth G. Bedingham, Bethany E. Pierce, L. Paul Sands, Craig W. Lindsley, Carrie K. Jones, Robert W. Gould
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Neuroscience
Subjects:
electroencephalography (EEG)
cognition
metabotropic glutamate receptor 5 (mGlu5)
negative allosteric modulator (NAM)
MK-801
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.700822/full

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https://www.frontiersin.org/articles/10.3389/fnins.2021.700822/full

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