SURF: integrative analysis of a compendium of RNA-seq and CLIP-seq datasets highlights complex governing of alternative transcriptional regulation by RNA-binding proteins

SURF: integrative analysis of a compendium of RNA-seq and CLIP-seq datasets highlights complex governing of alternative transcriptional regulation by RNA-binding proteins

Abstract Advances in high-throughput profiling of RNA-binding proteins (RBPs) have resulted inCLIP-seq datasets coupled with transcriptome profiling by RNA-seq. However, analysis methods that integrate both types of data are lacking. We describe SURF, Statistical Utility for RBP Functions, for integ...

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Bibliographic Details
Main Authors: Fan Chen, Sündüz Keleş
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Genome Biology
Subjects:
RNA-binding protein
CLIP-seq
RNA-seq
Integrative modeling
Differential analysis
Alternative splicing
Online Access:http://link.springer.com/article/10.1186/s13059-020-02039-7

Internet

http://link.springer.com/article/10.1186/s13059-020-02039-7

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