Design and In Vivo Pharmacokinetic Evaluation of Triamcinolone Acetonide Microcrystals-Loaded PLGA Microsphere for Increased Drug Retention in Knees after Intra-Articular Injection

Design and In Vivo Pharmacokinetic Evaluation of Triamcinolone Acetonide Microcrystals-Loaded PLGA Microsphere for Increased Drug Retention in Knees after Intra-Articular Injection

A novel polymeric microsphere (MS) containing micronized triamcinolone acetonide (TA) in a crystalline state was structured to provide extended drug retention in joints after intra-articular (IA) injection. Microcrystals with a median diameter of 1.7 μm were prepared by ultra-sonication met...

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Bibliographic Details
Main Authors: Myoung Jin Ho, Hoe Taek Jeong, Sung Hyun Im, Hyung Tae Kim, Jeong Eun Lee, Jun Soo Park, Ha Ra Cho, Dong Yoon Kim, Young Wook Choi, Joon Woo Lee, Yong Seok Choi, Myung Joo Kang
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Pharmaceutics
Subjects:
triamcinolone acetonide
microcrystal
PLGA microsphere
local delivery
spray-drying technique
intra-articular injection
joint retention
systemic exposure
Online Access:https://www.mdpi.com/1999-4923/11/8/419

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https://www.mdpi.com/1999-4923/11/8/419

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