Intranasal Delivery of Targeted Nanoparticles Loaded With miR-132 to Brain for the Treatment of Neurodegenerative Diseases

Intranasal Delivery of Targeted Nanoparticles Loaded With miR-132 to Brain for the Treatment of Neurodegenerative Diseases

Effective treatments for neurodegenerative diseases need to be developed. MiR132 is abundantly expressed in the brain, and it modulates neuron morphology and plays a key role in maintaining neuron survival. Regulating miR132 can effectively improve the symptoms of Alzheimer’s disease. It can also re...

Full description

Bibliographic Details
Main Authors:	Yu Su, Bixi Sun, Xiaoshu Gao, Xinyue Dong, Lanbo Fu, Yingxin Zhang, Zhulin Li, Yue Wang, Hongyu Jiang, Bing Han
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-08-01
Series:	Frontiers in Pharmacology
Subjects:	neurodegenerative diseases MiR132 nose to brain delivery nanoparticles wheat germ agglutinin
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2020.01165/full

Similar Items

Expression of miR-132 and miR-212 in prostate cancer and metastatic lymph node: Case report and revision of the literature
by: Michele Salemi, et al.
Published: (2020-10-01)

Expression and clinical significance of miR-132 in the plasma of patients with diabetic retinopathy
by: Ru Liu, et al.
Published: (2019-08-01)

Increased miR-132 level is associated with visual memory dysfunction in patients with depression
by: Liu Y, et al.
Published: (2016-11-01)

Relationship between circulating miR-132 and non-alcoholic fatty liver disease in a Chinese population
by: Yicen Zong, et al.
Published: (2020-05-01)

Advances in Roles of miR-132 in the Nervous System
by: Yun Qian, et al.
Published: (2017-10-01)

Advances and Challenges in Understanding MicroRNA Function in Tauopathies: A Case Study of miR-132/212
by: Emmanuelle Boscher, et al.
Published: (2020-09-01)

Wheat Germ Agglutinin—From Toxicity to Biomedical Applications
by: Gabrielė Balčiūnaitė-Murzienė, et al.
Published: (2021-01-01)

Long non-coding RNA MIAT promotes growth and metastasis of colorectal cancer cells through regulation of miR-132/Derlin-1 pathway
by: Zhaoxia Liu, et al.
Published: (2018-04-01)

miR-132 regulates the expression of synaptic proteins in APP/PS1 transgenic mice through C1q
by: Nan Xu, et al.
Published: (2019-05-01)

Molecular mechanisms of the microRNA-132 during tumor progressions
by: Meysam Moghbeli, et al.
Published: (2021-08-01)

MiR-132 as a Dynamic Regulator of Neuronal Structure and Cognitive Capacity
by: Hansen, Katelin Libby French
Published: (2015)

MiR-124 and the Underlying Therapeutic Promise of Neurodegenerative Disorders
by: Dong Han, et al.
Published: (2020-01-01)

Notoginsenoside R1 Protects HUVEC Against Oxidized Low Density Lipoprotein (Ox-LDL)-Induced Atherogenic Response via Down-Regulating miR-132
by: Changgeng Fu, et al.
Published: (2018-11-01)

miR-132/212 Impairs Cardiomyocytes Contractility in the Failing Heart by Suppressing SERCA2a
by: Zhiyong Lei, et al.
Published: (2021-03-01)

Decreased expression of miR-132 in CRC tissues and its inhibitory function on tumor progression
by: Yong Chen, et al.
Published: (2016-01-01)

Alzheimer’s Disease and microRNA-132: A Widespread Pathological Factor and Potential Therapeutic Target
by: Meng Zhang, et al.
Published: (2021-05-01)

Circ_DOCK1 regulates USP11 through miR-132-3p to control colorectal cancer progression
by: Weitong Zhang, et al.
Published: (2021-03-01)

MicroRNA-132 Negatively Regulates Palmitate-Induced NLRP3 Inflammasome Activation through FOXO3 Down-Regulation in THP-1 Cells
by: Hye-Eun Byeon, et al.
Published: (2017-12-01)

Supplemental Treatment for Huntington’s Disease with miR-132 that Is Deficient in Huntington’s Disease Brain
by: Masashi Fukuoka, et al.
Published: (2018-06-01)

Regulatory roles of the miR-200 family in neurodegenerative diseases
by: Jie Fu, et al.
Published: (2019-11-01)

Long noncoding RNA Sox2 overlapping transcript (SOX2OT) promotes non-small-cell lung cancer migration and invasion via sponging microRNA 132 (miR-132)
by: Zhang K, et al.
Published: (2018-08-01)

LncRNA SNHG5 regulates cell apoptosis and inflammation by miR-132/PTEN axis in COPD
by: Qin Shen, et al.
Published: (2020-06-01)

Reversible Lectin Binding to Glycan-Functionalized Graphene
by: Tereza Koukalová, et al.
Published: (2021-06-01)

Stevioside-induced molecular heterogeneity and lectin activity at low positive temperatures
by: Uliana Alexsandrovna Galikhanova, et al.
Published: (2020-12-01)

ABCA1-mediated cholesterol efflux generates microparticles in addition to HDL through processes governed by membrane rigidity[S]
by: Shilpi Nandi, et al.
Published: (2009-03-01)

Loss of miR-132/212 Has No Long-Term Beneficial Effect on Cardiac Function After Permanent Coronary Occlusion in Mice
by: Zhiyong Lei, et al.
Published: (2020-06-01)

miR-132-3p priming enhances the effects of mesenchymal stromal cell-derived exosomes on ameliorating brain ischemic injury
by: Qunwen Pan, et al.
Published: (2020-06-01)

Degradation of Wheat Germ Agglutinin during Sourdough Fermentation
by: Luis E. Rojas Tovar, et al.
Published: (2021-02-01)

Identification of hsa-miR-1275 as a Novel Biomarker Targeting MECP2 for Human Epilepsy of Unknown Etiology
by: Ye Zhao, et al.
Published: (2020-12-01)

MiRNA-132 regulates the development of osteoarthritis in correlation with the modulation of PTEN/PI3K/AKT signaling
by: Wei Zhang, et al.
Published: (2021-03-01)

Exosomes from Adipose-Derived Stem Cells Promotes VEGF-C-Dependent Lymphangiogenesis by Regulating miRNA-132/TGF-β Pathway
by: Xiaolei Wang, et al.
Published: (2018-08-01)

Analyses of bovine luteal fractions obtained by FACS reveals enrichment of miR-183-96-182 cluster miRNAs in endothelial cells
by: Bushra T. Mohammed, et al.
Published: (2019-05-01)

Detection of Glycomic Alterations Induced by Overexpression of P-Glycoprotein on the Surfaces of L1210 Cells Using Sialic Acid Binding Lectins
by: Albert Breier, et al.
Published: (2012-11-01)

miR-132 downregulation alleviates behavioral impairment of rats exposed to single prolonged stress, reduces the level of apoptosis in PFC, and upregulates the expression of MeCP2 and BDNF
by: Lei Tong, et al.
Published: (2021-05-01)

MiR-132-3p Regulates the Osteogenic Differentiation of Thoracic Ligamentum Flavum Cells by Inhibiting Multiple Osteogenesis-Related Genes
by: Xiaochen Qu, et al.
Published: (2016-08-01)

AhR Ligands Differentially Regulate miRNA-132 Which Targets HMGB1 and to Control the Differentiation of Tregs and Th-17 Cells During Delayed-Type Hypersensitivity Response
by: Osama A. Abdulla, et al.
Published: (2021-02-01)

Les microARN et la fonction gonadotrope hypophysaire
by: Lannes, Jérôme
Published: (2016)

MiR-132 Regulates Rem Expression in Cardiomyocytes During Long-Term β-Adrenoceptor Agonism
by: Elba D. Carrillo, et al.
Published: (2015-04-01)

Intranasal Delivery of Genistein-Loaded Nanoparticles as a Potential Preventive System against Neurodegenerative Disorders
by: Giovanna Rassu, et al.
Published: (2018-12-01)

Using 5-fluorouracil-encored plga nanoparticles for the treatment of colorectal cancer: the in-vitro characterization and cytotoxicity studies
by: Aditya Nath Pandey, et al.
Published: (2020-07-01)