Reduction of natural killer but not effector CD8 T lymphocytes in three consecutive cases of severe/lethal H1N1/09 influenza A virus infection.
BACKGROUND:The cause of severe disease in some patients infected with pandemic influenza A virus is unclear. METHODOLOGY/PRINCIPAL FINDINGS:We present the cellular immunology profile in the blood, and detailed clinical (and post-mortem) findings of three patients with rapidly progressive infection,...
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2010-05-01
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doaj-0a1e1fdc702d44d4a38fb4cd857c0ecc2020-11-25T02:14:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-05-0155e1067510.1371/journal.pone.0010675Reduction of natural killer but not effector CD8 T lymphocytes in three consecutive cases of severe/lethal H1N1/09 influenza A virus infection.Laura DenneyCelia AitkenChris Ka-Fai LiEleri Wilson-DaviesWai Ling KokColin ClellandKevin RooneyDuncan YoungTao DongAndrew J McMichaelWilliam F CarmanLing-Pei HoBACKGROUND:The cause of severe disease in some patients infected with pandemic influenza A virus is unclear. METHODOLOGY/PRINCIPAL FINDINGS:We present the cellular immunology profile in the blood, and detailed clinical (and post-mortem) findings of three patients with rapidly progressive infection, including a pregnant patient who died. The striking finding is of reduction in natural killer (NK) cells but preservation of activated effector CD8 T lymphocytes; with viraemia in the patient who had no NK cells. Comparison with control groups suggests that the reduction of NK cells is unique to these severely ill patients. CONCLUSION/SIGNIFICANCE:Our report shows markedly reduced NK cells in the three patients that we sampled and raises the hypothesis that NK may have a more significant role than T lymphocytes in controlling viral burden when the host is confronted with a new influenza A virus subtype.http://europepmc.org/articles/PMC2872666?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Laura Denney Celia Aitken Chris Ka-Fai Li Eleri Wilson-Davies Wai Ling Kok Colin Clelland Kevin Rooney Duncan Young Tao Dong Andrew J McMichael William F Carman Ling-Pei Ho |
spellingShingle |
Laura Denney Celia Aitken Chris Ka-Fai Li Eleri Wilson-Davies Wai Ling Kok Colin Clelland Kevin Rooney Duncan Young Tao Dong Andrew J McMichael William F Carman Ling-Pei Ho Reduction of natural killer but not effector CD8 T lymphocytes in three consecutive cases of severe/lethal H1N1/09 influenza A virus infection. PLoS ONE |
author_facet |
Laura Denney Celia Aitken Chris Ka-Fai Li Eleri Wilson-Davies Wai Ling Kok Colin Clelland Kevin Rooney Duncan Young Tao Dong Andrew J McMichael William F Carman Ling-Pei Ho |
author_sort |
Laura Denney |
title |
Reduction of natural killer but not effector CD8 T lymphocytes in three consecutive cases of severe/lethal H1N1/09 influenza A virus infection. |
title_short |
Reduction of natural killer but not effector CD8 T lymphocytes in three consecutive cases of severe/lethal H1N1/09 influenza A virus infection. |
title_full |
Reduction of natural killer but not effector CD8 T lymphocytes in three consecutive cases of severe/lethal H1N1/09 influenza A virus infection. |
title_fullStr |
Reduction of natural killer but not effector CD8 T lymphocytes in three consecutive cases of severe/lethal H1N1/09 influenza A virus infection. |
title_full_unstemmed |
Reduction of natural killer but not effector CD8 T lymphocytes in three consecutive cases of severe/lethal H1N1/09 influenza A virus infection. |
title_sort |
reduction of natural killer but not effector cd8 t lymphocytes in three consecutive cases of severe/lethal h1n1/09 influenza a virus infection. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2010-05-01 |
description |
BACKGROUND:The cause of severe disease in some patients infected with pandemic influenza A virus is unclear. METHODOLOGY/PRINCIPAL FINDINGS:We present the cellular immunology profile in the blood, and detailed clinical (and post-mortem) findings of three patients with rapidly progressive infection, including a pregnant patient who died. The striking finding is of reduction in natural killer (NK) cells but preservation of activated effector CD8 T lymphocytes; with viraemia in the patient who had no NK cells. Comparison with control groups suggests that the reduction of NK cells is unique to these severely ill patients. CONCLUSION/SIGNIFICANCE:Our report shows markedly reduced NK cells in the three patients that we sampled and raises the hypothesis that NK may have a more significant role than T lymphocytes in controlling viral burden when the host is confronted with a new influenza A virus subtype. |
url |
http://europepmc.org/articles/PMC2872666?pdf=render |
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