The Disruption of the β-Catenin/TCF-1/STAT3 Signaling Axis by 4-Acetylantroquinonol B Inhibits the Tumorigenesis and Cancer Stem-Cell-Like Properties of Glioblastoma Cells, In Vitro and In Vivo

The Disruption of the β-Catenin/TCF-1/STAT3 Signaling Axis by 4-Acetylantroquinonol B Inhibits the Tumorigenesis and Cancer Stem-Cell-Like Properties of Glioblastoma Cells, In Vitro and In Vivo

Background: Glioblastoma (GBM), a malignant form of glioma, is characterized by resistance to therapy and poor prognosis. Accumulating evidence shows that the initiation, propagation, and recurrence of GBM is attributable to the presence of GBM stem cells (GBM-CSCs). Experimental approach: Herein, w...

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Bibliographic Details
Main Authors: Heng-Wei Liu, Yu-Kai Su, Oluwaseun Adebayo Bamodu, Dueng-Yuan Hueng, Wei-Hwa Lee, Chun-Chih Huang, Li Deng, Michael Hsiao, Ming-Hsien Chien, Chi-Tai Yeh, Chien-Min Lin
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Cancers
Subjects:
glioblastoma
β-catenin
cancer stem cell
4-AAQB
chemoresistance
prognosis
survival
Online Access:https://www.mdpi.com/2072-6694/10/12/491

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https://www.mdpi.com/2072-6694/10/12/491

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