Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity.

Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity.

TRIMCyps are anti-retroviral proteins that have arisen independently in New World and Old World primates. All TRIMCyps comprise a CypA domain fused to the tripartite domains of TRIM5alpha but they have distinct lentiviral specificities, conferring HIV-1 restriction in New World owl monkeys and HIV-2...

Full description

Bibliographic Details
Main Authors: Laura M J Ylinen, Amanda J Price, Jane Rasaiyaah, Stéphane Hué, Nicola J Rose, Flavia Marzetta, Leo C James, Greg J Towers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2924388?pdf=render

Internet

http://europepmc.org/articles/PMC2924388?pdf=render

Similar Items