Multiscale Coupling of an Agent-Based Model of Tissue Fibrosis and a Logic-Based Model of Intracellular Signaling

Multiscale Coupling of an Agent-Based Model of Tissue Fibrosis and a Logic-Based Model of Intracellular Signaling

Wound healing and fibrosis following myocardial infarction (MI) is a dynamic process involving many cell types, extracellular matrix (ECM), and inflammatory cues. As both incidence and survival rates for MI increase, management of post-MI recovery and associated complications are an increasingly imp...

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Bibliographic Details
Main Authors: S. Michaela Rikard, Thomas L. Athey, Anders R. Nelson, Steven L. M. Christiansen, Jia-Jye Lee, Jeffrey W. Holmes, Shayn M. Peirce, Jeffrey J. Saucerman
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Physiology
Subjects:
fibrosis
cardiac fibroblast
myocardial infarction
systems biology
multiscale modeling
agent-based model
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01481/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.01481/full

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