The involvement of cholinergic neurons in the spreading of tau pathology

Long time ago, it was described the selective loss of cholinergic neurons during the development of Alzheimer disease. Recently, it has been suggested that tau protein may play a role in that loss of cholinergic neurons through a mechanism involving the interaction of extracellular tau with M1/M3 mu...

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Bibliographic Details
Main Authors: Diana eSimon, Felix eHernandez, Jesus eAvila
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-06-01
Series:Frontiers in Neurology
Subjects:
tau
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00074/full