Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways

Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways

Cyclotripeptide X-13 is a core of novel marine compound xyloallenoide A isolated from mangrove fungus <em>Xylaria</em> sp. (no. 2508). We found that X-13 dose-dependently induced angiogenesis in zebrafish embryos and in human endothelial cells, which was accompanied by in...

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Bibliographic Details
Main Authors: Zhong Pei, Hong-Shuo Sun, Li-Ping Wang, Ji-Yan Pang, Jing-Song Ou, Jin-Sheng Zeng, Ru-Xun Huang, Guang-Lei Wang, Yong-Cheng Lin, Jing Li, Cheng-Hui Ye, Feng-Juan Su, Xiao-Li Yao, Zhong-Liang Xu, Xi-Lin Lu
Format: Article
Language:English
Published: MDPI AG 2012-06-01
Series:Marine Drugs
Subjects:
angiogenesis
marine cyclotripeptide
zebrafish
endothelial nitric oxide synthase
xyloallenoide A
Online Access:http://www.mdpi.com/1660-3397/10/6/1307

Internet

http://www.mdpi.com/1660-3397/10/6/1307

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