Inhibition of Colony Stimulating Factor 1 Receptor Suppresses Neuroinflammation and Neonatal Hypoxic-Ischemic Brain Injury

Inhibition of Colony Stimulating Factor 1 Receptor Suppresses Neuroinflammation and Neonatal Hypoxic-Ischemic Brain Injury

Hypoxic-ischemic (HI) brain injury is a major cause of neonatal death or lifetime disability without widely accepted effective pharmacological treatments. It has been shown that the survival of microglia requires colony-stimulating factor 1 receptor (CSF1R) signaling and microglia participate in neo...

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Bibliographic Details
Main Authors: Bohao Zhang, Yunwei Ran, Siting Wu, Fang Zhang, Huachen Huang, Changlian Zhu, Shusheng Zhang, Xiaoan Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Neurology
Subjects:
colony stimulating factor 1 receptor
PLX3397
microglia
neuroinflammation
neonatal hypoxic-ischemic brain injury
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.607370/full

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https://www.frontiersin.org/articles/10.3389/fneur.2021.607370/full

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