Instability of Acylcarnitines in Stored Dried Blood Spots: The Impact on Retrospective Analysis of Biomarkers for Inborn Errors of Metabolism

Instability of Acylcarnitines in Stored Dried Blood Spots: The Impact on Retrospective Analysis of Biomarkers for Inborn Errors of Metabolism

Stored dried blood spots (DBS) can provide valuable samples for the retrospective diagnosis of inborn errors of metabolism, and for validation studies for newborn blood spot screening programs. Acylcarnitine species are subject to degradation upon long-term storage at room temperature, but limited d...

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Bibliographic Details
Main Authors: Willemijn J. van Rijt, Peter C. J. I. Schielen, Yasemin Özer, Klaas Bijsterveld, Fjodor H. van der Sluijs, Terry G. J. Derks, M. Rebecca Heiner-Fokkema
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Neonatal Screening
Subjects:
acylcarnitine
dried blood spot
inborn error of metabolism
metabolite instability
metabolite stability
newborn blood spot screening
Online Access:https://www.mdpi.com/2409-515X/6/4/83

Internet

https://www.mdpi.com/2409-515X/6/4/83

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