Human Newborn Monocytes Demonstrate Distinct BCG-Induced Primary and Trained Innate Cytokine Production and Metabolic Activation In Vitro

Human Newborn Monocytes Demonstrate Distinct BCG-Induced Primary and Trained Innate Cytokine Production and Metabolic Activation In Vitro

BackgroundNewborns exhibit distinct immune responses and are at high risk of infection. Neonatal immunization with BCG, the live attenuated vaccine against tuberculosis (TB), is associated with broad protection against a range of unrelated pathogens, possibly reflecting vaccine-induced training of i...

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Bibliographic Details
Main Authors: Asimenia Angelidou, Joann Diray-Arce, Maria-Giulia Conti, Mihai G. Netea, Bastiaan A. Blok, Mark Liu, Guzman Sanchez-Schmitz, Al Ozonoff, Simon D. van Haren, Ofer Levy
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
Bacille Calmette-Guérin (BCG) vaccine
cord blood
cytokines
lactate
newborn monocytes
immunometabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.674334/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.674334/full

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