New somatic TERT promoter variants enhance the Telomerase activity in Glioblastoma

New somatic TERT promoter variants enhance the Telomerase activity in Glioblastoma

Abstract The catalytic activity of human Telomerase Reverse Transcriptase (TERT) compensates for the loss of telomere length, eroded during each cell cycle, to ensure a correct division of stem and germinal cells. In human tumors, ectopic TERT reactivation, most frequently due to hotspot mutations i...

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Bibliographic Details
Main Authors: Tiziana Pierini, Carlotta Nardelli, Anair Graciela Lema Fernandez, Valentina Pierini, Fabrizia Pellanera, Valeria Nofrini, Paolo Gorello, Martina Moretti, Silvia Arniani, Giovanni Roti, Paolo Giovenali, Marco Lupattelli, Giulio Metro, Carmen Molica, Corrado Castrioto, Rodolfo Corinaldesi, Maria Elena Laurenti, Stefano Ascani, Cristina Mecucci, Roberta La Starza
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Acta Neuropathologica Communications
Subjects:
TERT
Gliomas
Gain-of-function mutation
ETS and Krüppel transcription factors
Online Access:http://link.springer.com/article/10.1186/s40478-020-01022-4

Internet

http://link.springer.com/article/10.1186/s40478-020-01022-4

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