Involvement of renal ACE activity in proteinuria-associated renal damage in untreated and treated adriamycin nephrotic rats

Proteinuria is assumed to play a pathogenetic role in progressive renal damage. Angiotensin-converting enzyme (ACE) inhibition reduces proteinuria and provides renoprotection. This suggests that ACE activity might play a pathogenetic role in the development of proteinuria-induced renal structural da...

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Bibliographic Details
Main Authors: Hendrik Bos, Gozewijn D Laverman, Robert H Henning, Anton TMG Tiebosch, Paul E de Jong, Dick de Zeeuw, Gerjan Navis
Format: Article
Language:English
Published: Hindawi - SAGE Publishing 2003-06-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.3317/jraas.2003.010