Ex vivo expansion and functional activity preservation of adult hematopoietic stem cells by a diarylheptanoid from Curcuma comosa

Ex vivo expansion and functional activity preservation of adult hematopoietic stem cells by a diarylheptanoid from Curcuma comosa

Hematopoietic stem cells (HSCs, CD34+ cells) have shown therapeutic efficacy for transplantation in various hematological disorders. However, a large quantity of HSCs is required for transplantation. Therefore, strategies to increase HSC numbers and preserve HSC functions through ex vivo culture are...

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Bibliographic Details
Main Authors: Nopmullee Tanhuad, Umnuaychoke Thongsa-ad, Nareerat Sutjarit, Ploychompoo Yoosabai, Wittaya Panvongsa, Sirapope Wongniam, Apichart Suksamrarn, Pawinee Piyachaturawat, Usanarat Anurathapan, Suparerk Borwornpinyo, Arthit Chairoungdua, Suradej Hongeng, Kanit Bhukhai
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Hematopoietic stem cells (HSCs)
Ex vivo expansion
Primitive HSCs
Repopulating HSCs
Diarylheptanoid
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221008866

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http://www.sciencedirect.com/science/article/pii/S0753332221008866

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