Comparing Gly11/dAla11-Replacement vs. the in-Situ Neprilysin-Inhibition Approach on the Tumor-targeting Efficacy of the 111In-SB3/111In-SB4 Radiotracer Pair

Comparing Gly11/dAla11-Replacement vs. the in-Situ Neprilysin-Inhibition Approach on the Tumor-targeting Efficacy of the 111In-SB3/111In-SB4 Radiotracer Pair

Background: The GRPR-antagonist 68Ga-SB3 visualized prostate cancer lesions in animal models and in patients. Switching radiometal from 68Ga to 111In impaired tumor targeting in mice, but coinjection of the neprilysin (NEP)-inhibitor phosphoramidon (PA) stabilized 111In-SB3 in circulation and remark...

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Bibliographic Details
Main Authors: Emmanouil Lymperis, Aikaterini Kaloudi, Panagiotis Kanellopoulos, Marion de Jong, Eric P. Krenning, Berthold A. Nock, Theodosia Maina
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
GRPR-antagonist
bombesin-like radioligand
tumor targeting
tumor imaging
neprilysin-inhibition
phosphoramidon
in vivo stability
Online Access:http://www.mdpi.com/1420-3049/24/6/1015

Internet

http://www.mdpi.com/1420-3049/24/6/1015

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