Salidroside Ameliorated Intermittent Hypoxia-Aggravated Endothelial Barrier Disruption and Atherosclerosis via the cAMP/PKA/RhoA Signaling Pathway

Salidroside Ameliorated Intermittent Hypoxia-Aggravated Endothelial Barrier Disruption and Atherosclerosis via the cAMP/PKA/RhoA Signaling Pathway

Background: Endothelial barrier dysfunction plays a key role in atherosclerosis progression. The primary pathology of obstructive sleep apnea-hypopnea syndrome is chronic intermittent hypoxia (IH), which induces reactive oxygen species (ROS) overproduction, endothelial barrier injury, and atheroscle...

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Bibliographic Details
Main Authors: Linyi Li, Yunyun Yang, Huina Zhang, Yunhui Du, Xiaolu Jiao, Huahui Yu, Yu Wang, Qianwen Lv, Fan Li, Qiuju Sun, Yanwen Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
atherosclerosis
obstructive sleep apnea-hypopnea syndrome
intermittent hypoxia
salidroside
endothelial barrier
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.723922/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.723922/full

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