Metformin Reverses the Enhanced Myocardial SR/ER–Mitochondria Interaction and Impaired Complex I-Driven Respiration in Dystrophin-Deficient Mice

Metformin Reverses the Enhanced Myocardial SR/ER–Mitochondria Interaction and Impaired Complex I-Driven Respiration in Dystrophin-Deficient Mice

Besides skeletal muscle dysfunction, Duchenne muscular dystrophy (DMD) exhibits a progressive cardiomyopathy characterized by an impaired calcium (Ca2+) homeostasis and a mitochondrial dysfunction. Here we aimed to determine whether sarco-endoplasmic reticulum (SR/ER)–mitochondria interactions and m...

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Bibliographic Details
Main Authors: Claire Angebault, Mathieu Panel, Mathilde Lacôte, Jennifer Rieusset, Alain Lacampagne, Jérémy Fauconnier
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Duchenne muscular dystrophy cardiomyopathy
mitochondria-associated ER membrane
mitochondrial calcium uniporter
MICU1
calcium
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.609493/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.609493/full

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