Impaired Intestinal Farnesoid X Receptor Signaling in Cystic Fibrosis MiceSummary

Impaired Intestinal Farnesoid X Receptor Signaling in Cystic Fibrosis MiceSummary

Background & Aims: The bile acid (BA)-activated farnesoid X receptor (FXR) controls hepatic BA synthesis and cell proliferation via the intestinal hormone fibroblast growth factor 19. Because cystic fibrosis (CF) is associated with intestinal dysbiosis, anomalous BA handling, and biliary cirrhos...

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Bibliographic Details
Main Authors: Pauline T. Ikpa, Marcela Doktorova, Kelly F. Meijsen, Natascha D.A. Nieuwenhuijze, Henkjan J. Verkade, Johan W. Jonker, Hugo R. de Jonge, Marcel J.C. Bijvelds
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X19301122

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http://www.sciencedirect.com/science/article/pii/S2352345X19301122

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