Computing threshold antibody levels of protection in vaccine clinical trials: An assessment of methodological bias.

In the development of new vaccines, understanding the level of vaccine-induced antibody that is sufficient to protect against disease can simplify and expedite the development and licensing process. If there is an accepted threshold antibody level that is indicative of protection, then smaller trial...

Full description

Bibliographic Details
Main Authors: Merryn Voysey, Manish Sadarangani, Andrew J Pollard, Thomas R Fanshawe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6128451?pdf=render