Increase of Antitumoral Effects of Cytokine-Induced Killer Cells by Antibody-Mediated Inhibition of MICA Shedding

Increase of Antitumoral Effects of Cytokine-Induced Killer Cells by Antibody-Mediated Inhibition of MICA Shedding

Natural killer group 2D (NKG2D) receptor plays a pivotal role in cytokine-induced killer (CIK) cell-mediated cytotoxicity against malignancies, and the expression of NKG2D ligands might allow targets to be more susceptible to the CIK cell-mediated destruction. In this study, we investigated the syne...

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Bibliographic Details
Main Authors: Xiaolong Wu, Ying Zhang, Yutao Li, Ingo G.H. Schmidt-Wolf
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
cytokine-induced killer (CIK) cells
MICA/B
NKG2D
shed MICA
monoclonal antibody
Online Access:https://www.mdpi.com/2072-6694/12/7/1818

Internet

https://www.mdpi.com/2072-6694/12/7/1818

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