The Modulation of Cellular Susceptibility to Oxidative Stress: Protective and Destructive Actions of Cu,Zn-Superoxide Dismutase

Alterations in the activity of Cu,Zn-superoxide dismutase (SOD1), an enzyme that converts superoxide (O·−2) to hydrogen peroxide (H2O2) plus O2, have been found to affect cellular susceptibility to oxidative stress and have been invoked as a pathogenetic mechanism in a variety of neurodegenerative d...

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Bibliographic Details
Main Authors: Jun Xing, Yip Yu, Thomas A. Rando
Format: Article
Language:English
Published: Elsevier 2002-08-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102905048