Effects of Naturally Occurring Mutations in Bovine Leukemia Virus 5′-LTR and Tax Gene on Viral Transcriptional Activity

Effects of Naturally Occurring Mutations in Bovine Leukemia Virus 5′-LTR and Tax Gene on Viral Transcriptional Activity

Bovine leukemia virus (BLV) is a deltaretrovirus infecting bovine B cells and causing enzootic bovine leucosis (EBL). The long terminal repeat (LTR) plays an indispensable role in viral gene expression. The BLV Tax protein acts as the main transactivator of LTR-driven transcription of BLV viral gene...

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Bibliographic Details
Main Authors: Aneta Pluta, Luc Willems, Renée N. Douville, Jacek Kuźmak
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Pathogens
Subjects:
retrovirus, bovine leukemia virus (BLV), long terminal repeat (LTR), Tax protein, transactivation, transcription factor, proviral load, sequence variants, primary isolates
Online Access:https://www.mdpi.com/2076-0817/9/10/836

Internet

https://www.mdpi.com/2076-0817/9/10/836

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