Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability

Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability

The conserved long noncoding RNA Chaserr is transcribed upstream of the chromatin remodeler Chd2. Here, using mouse genetics and high throughput assays, the authors show that Chaserr inhibits expression of Chd2 in cis and is required for postnatal mouse development.

Bibliographic Details
Main Authors: Aviv Rom, Liliya Melamed, Noa Gil, Micah Jonathan Goldrich, Rotem Kadir, Matan Golan, Inbal Biton, Rotem Ben-Tov Perry, Igor Ulitsky
Format: Article
Language:English
Published: Nature Publishing Group 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13075-8

Internet

https://doi.org/10.1038/s41467-019-13075-8

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