Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune system.

Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune system.

Evidence is lacking for direct pathogenicity of human anti-proteinase-3 (PR3) antibodies in development of systemic vasculitis and granulomatosis with polyangiitis (GPA, Wegener's granulomatosis). Progress in study of these antibodies in rodents has been hampered by lack of PR3 expression on mu...

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Bibliographic Details
Main Authors: Mark A Little, Bahjat Al-Ani, Shuyu Ren, Hamad Al-Nuaimi, Maurilo Leite, Charles E Alpers, Caroline O Savage, Jeremy S Duffield
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3256135?pdf=render

Internet

http://europepmc.org/articles/PMC3256135?pdf=render

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