PARTICLE, a Triplex-Forming Long ncRNA, Regulates Locus-Specific Methylation in Response to Low-Dose Irradiation

PARTICLE, a Triplex-Forming Long ncRNA, Regulates Locus-Specific Methylation in Response to Low-Dose Irradiation

Exposure to low-dose irradiation causes transiently elevated expression of the long ncRNA PARTICLE (gene PARTICLE, promoter of MAT2A-antisense radiation-induced circulating lncRNA). PARTICLE affords both a cytosolic scaffold for the tumor suppressor methionine adenosyltransferase (MAT2A) and a nucle...

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Bibliographic Details
Main Authors: Valerie Bríd O’Leary, Saak Victor Ovsepian, Laura Garcia Carrascosa, Fabian Andreas Buske, Vanja Radulovic, Maximilian Niyazi, Simone Moertl, Matt Trau, Michael John Atkinson, Nataša Anastasov
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715003228

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http://www.sciencedirect.com/science/article/pii/S2211124715003228

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