Melatonin as a therapy in cardiac ischemia-reperfusion injury: Potential mechanisms by which MT2 activation mediates cardioprotection

Melatonin as a therapy in cardiac ischemia-reperfusion injury: Potential mechanisms by which MT2 activation mediates cardioprotection

Introduction: Previous studies reported the beneficial effects of pretreatment with melatonin on the heart during cardiac ischemia/reperfusion (I/R) injury. However, the effects of melatonin given after cardiac ischemia, as well as its comparative temporal effects are unknown. These include pretreat...

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Bibliographic Details
Main Authors: Kodchanan Singhanat, Nattayaporn Apaijai, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Siriporn C. Chattipakorn, Nipon Chattipakorn
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Journal of Advanced Research
Subjects:
Cardiac I/R injury
Melatonin
Melatonin receptors
Left ventricular function
Mitochondria
Cardiomyocyte death
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123220302174

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http://www.sciencedirect.com/science/article/pii/S2090123220302174

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