Shiga Toxin 1, as DNA Repair Inhibitor, Synergistically Potentiates the Activity of the Anticancer Drug, Mafosfamide, on Raji Cells

Shiga Toxin 1, as DNA Repair Inhibitor, Synergistically Potentiates the Activity of the Anticancer Drug, Mafosfamide, on Raji Cells

Shiga toxin 1 (Stx1), produced by pathogenic Escherichia coli, targets a restricted subset of human cells, which possess the receptor globotriaosylceramide (Gb3Cer/CD77), causing hemolytic uremic syndrome. In spite of the high toxicity, Stx1 has been proposed in the treatment of Gb3Cer/CD77-expressi...

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Bibliographic Details
Main Authors: Piero Sestili, Pier Giorgio Petronini, Roberta R. Alfieri, Pier Luigi Tazzari, Francesca Ricci, Pasqualepaolo Pagliaro, Laura Rocchi, Cinzia Calcabrini, Maurizio Brigotti, Valentina Arfilli, Domenica Carnicelli
Format: Article
Language:English
Published: MDPI AG 2013-02-01
Series:Toxins
Subjects:
Shiga toxin 1
Gb3Cer/CD77-expressing lymphomas
mafosfamide
DNA repair
autologous bone marrow transplantation
Online Access:http://www.mdpi.com/2072-6651/5/2/431

Internet

http://www.mdpi.com/2072-6651/5/2/431

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