Structural insights into substrate selectivity of ribosomal RNA methyltransferase RlmCD.

RlmCD has recently been identified as the S-adenosyl methionine (SAM)-dependent methyltransferase responsible for the formation of m5U at U747 and U1939 of 23S ribosomal RNA in Streptococcus pneumoniae. In this research, we determine the high-resolution crystal structures of apo-form RlmCD and its c...

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Bibliographic Details
Main Authors: Yiyang Jiang, Fudong Li, Jihui Wu, Yunyu Shi, Qingguo Gong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5614603?pdf=render