Mdivi-1 inhibits astrocyte activation and astroglial scar formation and enhances axonal regeneration after spinal cord injury in rats

Mdivi-1 inhibits astrocyte activation and astroglial scar formation and enhances axonal regeneration after spinal cord injury in rats

After spinal cord injury (SCI), astrocytes become hypertrophic and proliferative, forming a dense network of astroglial processes at the site of the lesion. This constitutes a physical and biochemical barrier to axonal regeneration. Mitochondrial fission regulates cell cycle progression; inhibiting...

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Bibliographic Details
Main Authors: gang li, yang cao, feifei shen, yansong wang, liangjie bai, weidong guo, yunlong bi, Gang Lv, zhongkai fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Astrocytes
spinal cord injury
axonal regeneration
astroglial scar
mitochondrial division inhibitor-1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00241/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00241/full

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