Endurance exercise resistance to lipotoxic cardiomyopathy is associated with cardiac NAD+/dSIR2/PGC-1α pathway activation in old Drosophila
Lipotoxic cardiomyopathy is caused by excessive lipid accumulation in myocardial cells and it is a form of cardiac dysfunction. Cardiac PGC-1α overexpression prevents lipotoxic cardiomyopathy induced by a high-fat diet (HFD). The level of NAD+ and Sir2 expression upregulate the transcriptional activ...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
The Company of Biologists
2019-10-01
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Series: | Biology Open |
Subjects: | |
Online Access: | http://bio.biologists.org/content/8/10/bio044719 |