Endurance exercise resistance to lipotoxic cardiomyopathy is associated with cardiac NAD+/dSIR2/PGC-1α pathway activation in old Drosophila

Endurance exercise resistance to lipotoxic cardiomyopathy is associated with cardiac NAD+/dSIR2/PGC-1α pathway activation in old Drosophila

Lipotoxic cardiomyopathy is caused by excessive lipid accumulation in myocardial cells and it is a form of cardiac dysfunction. Cardiac PGC-1α overexpression prevents lipotoxic cardiomyopathy induced by a high-fat diet (HFD). The level of NAD+ and Sir2 expression upregulate the transcriptional activ...

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Bibliographic Details
Main Authors: Deng-Tai Wen, Lan Zheng, Jin-xiu Li, Dan Cheng, Yang Liu, Kai Lu, Wen-qi Hou
Format: Article
Language:English
Published: The Company of Biologists 2019-10-01
Series:Biology Open
Subjects:
heart
dsir2
nad+
pgc-1α
exercise
high-fat diet
Online Access:http://bio.biologists.org/content/8/10/bio044719

Internet

http://bio.biologists.org/content/8/10/bio044719

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