RBM45 associates with nuclear stress bodies and forms nuclear inclusions during chronic cellular stress and in neurodegenerative diseases

RBM45 associates with nuclear stress bodies and forms nuclear inclusions during chronic cellular stress and in neurodegenerative diseases

Abstract The RNA binding protein (RBP) RBM45 forms nuclear and cytoplasmic inclusions in neurons and glia in amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP), and Alzheimer’s disease (AD). The normal functions of RBM45 are poorly understood,...

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Bibliographic Details
Main Authors: Mahlon Collins, Yang Li, Robert Bowser
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Acta Neuropathologica Communications
Subjects:
RBM45
Nuclear stress bodies
Protein inclusions
Frontotemporal lobar degeneration
Amyotrophic lateral sclerosis
RNA binding proteins
Online Access:http://link.springer.com/article/10.1186/s40478-020-00965-y

Internet

http://link.springer.com/article/10.1186/s40478-020-00965-y

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