Oncogenic BRAF(V600E) Induces Clastogenesis and UVB Hypersensitivity

The oncogenic BRAF(V600E) mutation is common in melanomas as well as moles. The roles that this mutation plays in the early events in the development of melanoma are poorly understood. This study demonstrates that expression of BRAF(V600E) is not only clastogenic, but synergizes for clastogenesis ca...

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Bibliographic Details
Main Authors: Dennis A. Simpson, Nathalay Lemonie, David S. Morgan, Shobhan Gaddameedhi, William K. Kaufmann
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Cancers
Subjects:
UVB
Online Access:http://www.mdpi.com/2072-6694/7/2/0825