Miniaturized shake-flask HPLC method for determination of distribution coefficient of drugs used in inflammatory bowel diseases

A new method for determination of distribution coefficient of drugs azathioprine, 6-mercaptopurine and 6-thioguanine and nutrient folic acid used in the treatment of inflammatory bowel disease based on a miniaturized shake-flask and HPLC/DAD was developed. Special attention was made to the most comm...

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Bibliographic Details
Main Authors: Brusač Edvin, Jeličić Mario-Livio, Klarić Daniela Amidžić, Mornar Ana
Format: Article
Language:English
Published: Sciendo 2019-12-01
Series:Acta Pharmaceutica
Subjects:
Online Access:https://doi.org/10.2478/acph-2019-0046