Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice

Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice

Interleukin-6 (IL-6) has emerged as an important mediator of fatty acid metabolism with paradoxical effects in the liver. Administration of IL-6 has been reported to confer protection against steatosis, but plasma and tissue IL-6 concentrations are elevated in chronic liver diseases, including fatty...

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Bibliographic Details
Main Authors: Margarita Vida, Ana Luisa Gavito, Francisco Javier Pavón, Dolores Bautista, Antonia Serrano, Juan Suarez, Sergio Arrabal, Juan Decara, Miguel Romero-Cuevas, Fernando Rodríguez de Fonseca, Elena Baixeras
Format: Article
Language:English
Published: The Company of Biologists 2015-07-01
Series:Disease Models & Mechanisms
Subjects:
Interleukin-6
Liver
Lipogenesis
Steatosis
Online Access:http://dmm.biologists.org/content/8/7/721

Internet

http://dmm.biologists.org/content/8/7/721

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