The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth

The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth

Peppi Koivunen,1 Stuart M Fell,2,3 Wenyun Lu,4 Joshua D Rabinowitz,4 Andrew L Kung,5,6 Susanne Schlisio,2,7 1Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland; 2Ludwig Institute for Cancer Research Ltd, St...

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Bibliographic Details
Main Authors: Koivunen P, Fell SM, Lu W, Rabinowitz JD, Kung AL, Schlisio S
Format: Article
Language:English
Published: Dove Medical Press 2016-03-01
Series:Hypoxia
Subjects:
hypoxia-inducible transcription factor HIF1a
prolyl hydroxylase
2-oxoglutarate analogue
cancer cell survival
cell death
combinatorial therapeutic drug
Online Access:https://www.dovepress.com/the-2-oxoglutarate-analog-3-oxoglutarate-decreases-normoxic-hypoxia-in-peer-reviewed-article-HP

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https://www.dovepress.com/the-2-oxoglutarate-analog-3-oxoglutarate-decreases-normoxic-hypoxia-in-peer-reviewed-article-HP

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