Design of novel granulopoietic proteins by topological rescaffolding.

Computational protein design is rapidly becoming more powerful, and improving the accuracy of computational methods would greatly streamline protein engineering by eliminating the need for empirical optimization in the laboratory. In this work, we set out to design novel granulopoietic agents using...

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Bibliographic Details
Main Authors: Birte Hernandez Alvarez, Julia Skokowa, Murray Coles, Perihan Mir, Masoud Nasri, Kateryna Maksymenko, Laura Weidmann, Katherine W Rogers, Karl Welte, Andrei N Lupas, Patrick Müller, Mohammad ElGamacy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-12-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000919