Type I error control for cluster randomized trials under varying small sample structures

Abstract Background Linear mixed models (LMM) are a common approach to analyzing data from cluster randomized trials (CRTs). Inference on parameters can be performed via Wald tests or likelihood ratio tests (LRT), but both approaches may give incorrect Type I error rates in common finite sample sett...

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Bibliographic Details
Main Authors: Joshua R. Nugent, Ken P. Kleinman
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Medical Research Methodology
Subjects:
Online Access:https://doi.org/10.1186/s12874-021-01236-7