IGF-1 promotes Brn-4 expression and neuronal differentiation of neural stem cells via the PI3K/Akt pathway.

IGF-1 promotes Brn-4 expression and neuronal differentiation of neural stem cells via the PI3K/Akt pathway.

Our previous studies indicated that transcription factor Brn-4 is upregulated in the surgically denervated hippocampus in vivo, promoting neuronal differentiation of hippocampal neural stem cells (NSCs) in vitro. The molecules mediating Brn-4 upregulation in the denervated hippocampus remain unknown...

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Bibliographic Details
Main Authors: Xinhua Zhang, Lei Zhang, Xiang Cheng, Yuxiu Guo, Xiaohui Sun, Geng Chen, Haoming Li, Pengcheng Li, Xiaohui Lu, Meiling Tian, Jianbing Qin, Hui Zhou, Guohua Jin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4256305?pdf=render

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http://europepmc.org/articles/PMC4256305?pdf=render

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