Mutant KRAS promotes malignant pleural effusion formation

Mutant KRAS promotes malignant pleural effusion formation

Malignant pleural effusion (MPE) is a lethal condition associated with various cancers. Here, the authors show that cancer cells withKRASmutations promote MPE by recruiting myeloid cells via CCL2 signalling and that pharmaceutical targeting of KRAS results in reduced MPE incidence and volume in mous...

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Bibliographic Details
Main Authors: Theodora Agalioti, Anastasios D. Giannou, Anthi C. Krontira, Nikolaos I. Kanellakis, Danai Kati, Malamati Vreka, Mario Pepe, Magda Spella, Ioannis Lilis, Dimitra E. Zazara, Eirini Nikolouli, Nikolitsa Spiropoulou, Andreas Papadakis, Konstantina Papadia, Apostolos Voulgaridis, Vaggelis Harokopos, Panagiota Stamou, Silke Meiners, Oliver Eickelberg, Linda A. Snyder, Sophia G. Antimisiaris, Dimitrios Kardamakis, Ioannis Psallidas, Antonia Marazioti, Georgios T. Stathopoulos
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15205

Internet

https://doi.org/10.1038/ncomms15205

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