Demethylation by low-dose 5-aza-2′-deoxycytidine impairs 3D melanoma invasion partially through miR-199a-3p expression revealing the role of this miR in melanoma

Demethylation by low-dose 5-aza-2′-deoxycytidine impairs 3D melanoma invasion partially through miR-199a-3p expression revealing the role of this miR in melanoma

Abstract Background Efficient treatments against metastatic melanoma dissemination are still lacking. Here, we report that low-cytotoxic concentrations of 5-aza-2′-deoxycytidine, a DNA demethylating agent, prevent in vitro 3D invasiveness of metastatic melanoma cells and reduce lung metastasis forma...

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Bibliographic Details
Main Authors: Cécile Desjobert, Arnaud Carrier, Audrey Delmas, Diego M. Marzese, Antoine Daunay, Florence Busato, Arnaud Pillon, Jörg Tost, Joëlle Riond, Gilles Favre, Chantal Etievant, Paola B. Arimondo
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Clinical Epigenetics
Subjects:
DNA methylation
microRNA
Melanoma aggressiveness
Epigenetics
Online Access:http://link.springer.com/article/10.1186/s13148-018-0600-2

Internet

http://link.springer.com/article/10.1186/s13148-018-0600-2

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