Pharmacogenetic evaluation of ABCB1, Cyp2C9, Cyp2C19 and methylene tetrahydrofolate reductase polymorphisms in teratogenicity of anti-epileptic drugs in women with epilepsy

Pharmacogenetic evaluation of ABCB1, Cyp2C9, Cyp2C19 and methylene tetrahydrofolate reductase polymorphisms in teratogenicity of anti-epileptic drugs in women with epilepsy

Aim: Pregnancy in women with epilepsy (WWE) who are on anti-epileptic drugs (AEDs) has two- to three-fold increased risk of fetal malformations. AEDs are mostly metabolized by Cyp2C9, Cyp2C19 and Cyp3A4 and transported by ABCB1. Patients on AED therapy can have folate deficiency. We hypothesize that...

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Bibliographic Details
Main Authors: Manna Jose, Moinak Banerjee, Anila Mathew, Tashi Bharadwaj, Neetha Vijayan, Sanjeev V Thomas
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2014-01-01
Series:Annals of Indian Academy of Neurology
Subjects:
ABCB1
anti-epileptic drugs
Cyp2C19
Cyp2C9
epilepsy
methylene tetrahydrofolate reductase
pharmacogenomics
South India
teratogenic
Online Access:http://www.annalsofian.org/article.asp?issn=0972-2327;year=2014;volume=17;issue=3;spage=259;epage=266;aulast=Jose

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http://www.annalsofian.org/article.asp?issn=0972-2327;year=2014;volume=17;issue=3;spage=259;epage=266;aulast=Jose

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